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Product
Anti-infective Products (Gatiquin)
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Tafrom(I V Injection Tafrom I V Injection)
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Tafrom
I V Injection Tafrom I V Injection
COMPOSITION
Tafrom I V injection
Each vial of 1.0 gm contains cefpirome sulphate equivalent to 1.0 gm Cefpirome.
Excipient: Anhydrous Sodium Carbonate.
Each vial contains sterile water for injection IP 10 ml.
Indications
Tafrom is indicated for the treatment of serious or life-threatening infections in adults caused by bacterial organisms sensitive to cefpirome.
• Lower respiratory tract infections (bronchopneumonia, lobar pneumonia).
• Infections in neutropenic patients.
• Bacteraemia/septicaemia.
• Complicated upper (pyelonephritis) and lower urinary tract infections.
• Skin and skin structure infections (eg. cellulitis, wound infections).
• Other serious ICU infections. |
Dosage And Administration
Tafrom is for intravenous use only; the dosage, mode of administration and duration of treatment depend upon the severity of the infection, sensitivity of the pathogens, condition of the patient and renal function.
The following dosages are recommended for infections in patients with normal renal function (creatinine clearance > 50 mL/min):
• Patients with Renal Insufficiency
Cefpirome is excreted principally by the kidney. The dose must therefore be reduced in patients with impaired renal function to compensate for the slower excretion. The following loading and regular dosages are recommended
Based on the serum creatinine level, creatinine clearance can be calculated using the following formula (Cockcroft`s equation):
• Men: body weight (kg) x (140 – age in years)
Creatinine clearance (mL/min) = 72 x serum creatinine (mg/dL)
• Women: Multiplication of the result of the above equation by 0.85.
Elderly
No dosage adjustment is required unless renal impairment is present.
Intravenous Injection
The contents of one vial of Tafrom 1.0 (equal to 1.0 g of cefpirome) are dissolved in 10 ml sterile water for injection, and then injected over 3 to 5 minutes either directly into a vein or into the distal section of a clamped-off infusion tube.
Short Intravenous Infusion
The contents of one 1.0 g of Tafrom are dissolved in 100 ml sterile water for injection and then infused over 20 to 30 minutes. The following infusion solutions may also be used: 0.9% sodium chloride solution, Ringer`s solution, 5% and 10% glucose solutions, 5% fructose solution.
Tafrom should not be mixed with any other antibiotics in the same syringe or with any other infusion solutions other than those mentioned above. The vials containing the solvent and the powder for reconstitution should be held horizontally when preparing the infusion solution, and the cannula should be inserted rapidly. The amount of 100 mL solvent must be adhered to as precisely as possible. This can be easily checked against a line marked at the side of the label of the vial.
Effervescence occurs on dissolution of the contents of the vial containing Cefpirome sulphate. The vial has to be tipped gently from side to side until its contents are completely dissolved. This may take up to five minutes.
Contraindications
Tafrom should not be used in patients with a known hypersensitivity to cephalosporins or a past history of serious allergic reaction to penicillin.
Presentation
Tafrom I.V. Injection..................................Vial of 1 gm
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